Table 1.
Baseline Characteristics of Entire Cohort and by HCV Status
| Characteristic | Entire cohort | HCV status unknown* | HCV positive | HCV negative | p value† |
|---|---|---|---|---|---|
| N = 34,810 | N = 1165 | N = 3673 | N = 29,972 | ||
| Age (median, IQR) | 59 (55–64) | 59 (55–63) | 60 (55–64) | 59 (55–64) | < 0.001 |
| Birth year (n, %) | |||||
| 1960–1965 | 11,832 (34.0) | 380 (32.6) | 1077 (29.3) | 10,375 (34.6) | < 0.001 |
| 1955–1959 | 9748 (28.0) | 346 (29.7) | 1107 (30.1) | 8295 (27.7) | |
| 1950–1954 | 8402 (24.1) | 305 (26.2) | 1002 (27.3) | 7095 (23.7) | |
| 1945–1949 | 4828 (13.9) | 134 (11.5) | 487 (13.3) | 4207 (14.0) | |
| Race (n, %) | |||||
| White | 8869 (25.5) | 483 (41.5) | 1400 (38.1) | 6986 (23.3) | < 0.001 |
| Black | 7159 (20.6) | 453 (38.9) | 1584 (43.1) | 5122 (17.1) | |
| Latino | 6162 (17.7) | 131 (11.3) | 426 (11.6) | 5605 (18.7) | |
| Asian/PI | 11,501 (33.0) | 58 (5.0) | 190 (5.2) | 11,253 (37.6) | |
| Other | 692 (2.0) | 21 (1.8) | 51 (1.4) | 620 (2.1) | |
| Missing | 427 (1.2) | 19 (1.6) | 22 (0.6) | 386 (1.3) | |
| Gender (n, %) | |||||
| Male | 20,058 (57.6) | 864 (74.2) | 2685 (73.1) | 16,509 (55.1) | < 0.001 |
| Female | 14,752 (42.4) | 301 (25.8) | 988 (26.9) | 13,463 (44.9) | |
| English as preferred language (n, %) | |||||
| Yes | 19,510 (56.1) | 807 (69.3) | 3049 (83.0) | 15,654 (52.2) | < 0.001 |
| No | 11,349 (32.6) | 42 (3.6) | 185 (5.0) | 11,122 (37.1) | |
| Missing | 3951 (11.4) | 316 (27.1) | 439 (12.0) | 3196 (10.7) | |
| CKD (n, %) | |||||
| Present | 4575 (13.1) | 235 (20.2) | 749 (20.4) | 3591 (12.0) | < 0.001 |
| Absent | 21,018 (60.4) | 376 (32.3) | 2912 (79.3) | 17,730 (59.2) | |
| Missing | 9217 (26.5) | 554 (47.6) | 12 (0.3) | 8651 (28.9) | |
| HBV co-infection (n, %) | |||||
| Positive | 1398 (4.0) | 22 (1.9) | 53 (1.4) | 1323 (4.4) | < 0.001 |
| Negative | 30,579 (87.9) | 958 (82.2) | 3386 (92.2) | 26,235 (87.5) | |
| Missing | 2833 (8.1) | 185 (15.9) | 234 (6.4) | 2414 (8.1) | |
| HIV co-infection (n, %) | |||||
| Positive | 1202 (3.5) | 26 (2.2) | 590 (16.1) | 586 (2.0) | < 0.001 |
| Negative | 24,281 (69.8) | 762 (65.4) | 2903 (79.0) | 20,616 (68.8) | |
| Missing | 9327 (26.8) | 377 (32.4) | 180 (4.9) | 8770 (29.3) | |
*HCV status based on HCVRNA testing. Unknown defined as lack of antibody or confirmatory HCVRNA testing. †p value for HCV status, considered statistically significant if < 0.05. CKD, chronic kidney disease, defined as eGFR ≤ 60 mL/min/1.73 m2. HBV co-infection, hepatitis B virus, defined as hepatitis B surface antigen positive. HCV, hepatitis C virus. HIV co-infection, human immunodeficiency virus, defined as the presence of HIV antibody. PI, Pacific Islander