Figure 1.

Individual proteins and cell populations measured in stable and exacerbation states. (a) Volcano plot illustrates serum proteins that are both differentially expressed (x axis) and significantly different (y axis) between the stable and exacerbated state. Significance was determined using non-normalized data (Supplemental Figures S1, S2 and S3), and points in red indicate significantly different expression between the stable and exacerbated state via paired Wilcoxon signed rank test, with significance being defined as p < 0.05. (b) Volcano plot highlighting significantly different sputum proteins across the stable and exacerbated state. Significance was determined as described above (p < 0.05). (c) Volcano plot illustrating blood cell marker measurements that were significantly different between stable and AE-COPD. Significance was determined as described above (p < 0.05).