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. 2019 May 8;12(5):389–397. doi: 10.1007/s12195-019-00573-4

Figure 1.

Figure 1

QUANT DNA sequences for sensitive in vivo readouts of nanoparticle biodistribution. (a) QUANT barcodes contain a ddPCR probe site flanked by forward and reverse primer sites. (b) Structure of ionizable lipid (MC3 or cKK-E12), cholesterol, PEG-lipid, and DSPC used in each LNP formulation. (c) Molar ratio of each LNP. (d) Nanoparticle biomaterials and QUANT barcodes are formulated into stable LNPs by microfluidic mixing. (e) Hydrodynamic diameter, measured by dynamic light scattering, of MC3 and cKK-E12 LNPs. N = 3/group (f) Polydispersity index (PDI) of MC3 and cKK-E12 LNPs. N = 3/group. Error bars are reported as standard error.