Skip to main content
. 2019 May 8;12(5):389–397. doi: 10.1007/s12195-019-00573-4

Figure 2.

Figure 2

Biodistribution of MC3 and cKK-E12 within the liver microenvironment. (a) As LNPs travel through the liver, they encounter Kupffer cells, endothelial cells and hepatocytes. (b) DNA delivery as mediated by cKK-E12 to endothelial cells, hepatocytes, and Kupffer cells. *p < 0.05, One-way ANOVA with Tukey’s Multiple Comparison. (c) DNA delivery as mediated by MC3 to endothelial cells, hepatocytes, and Kupffer cells. (d) Normalized DNA delivery (to hepatocytes) by cKK-E12 and MC3 reveals similar intra-hepatic biodistribution patterns. (e) Comparison of DNA delivery by cKK-E12 and MC3 to major liver cell types. *p < 0.05, Two-way ANOVA. Error bars are reported as standard error.