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. 2017 Oct 24;11(1):37–52. doi: 10.1007/s12195-017-0512-9

Figure 7.

Figure 7

Gal-1hFc treatment of ZR-75-1 breast cancer cells significantly reduces E-selectin interaction with cells in flow but has no effect in static adhesion assays. (a) ZR-75-1 breast cancer cells were treated with Gal-1hFc or an hFc control, then perfused over E-selectin and hFc control plates. Gal-1hFc treatment of ZR-75-1 cells in flow significantly reduces interactions to E-selectin coated plates (*p = 0.047) when compared to hFc control treated cells. Data are mean ± standard error, n = 3 independent experiments. (b) ZR-75-1 cells were treated with Gal-1hFc or a negative control, then incubated on E-selectin or isotype control-treated cell culture wells in separate static adhesion assays. There was no significant difference (p > 0.05) in the number of cell interactions with E-selectin plates between Gal-1hFc treated cells and the negative control. E-selectin plates were significantly different (*p = 0.008) in the number of interactions with both cell lines compared to the negative controls. Data are mean ± standard error, n = 3 independent experiments.