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PLGA microparticle depots for controlled release of endosomolytic nanoparticles. (a) PLGA MP depots mediate local nanoparticle release and subsequent intracellular delivery of nucleic acid to local cell populations. (b) Structure and composition of the endosomolytic diblock copolymers used for cytosolic nucleic acid delivery. (c) Representative scanning electron microscopy (SEM) images of nonporous microparticles (left) and porous microparticles (right). Scale: 3 µm.
