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. 2019 May 3;12(5):429–442. doi: 10.1007/s12195-019-00571-6

Figure 2.

Figure 2

In vitro characterization of PLGA microparticle depots. (a) Particle size distribution of nonporous and porous MPs determined by laser diffraction particle sizing. (b) In vitro release profiles of NPs from porous and nonporous MP depots over a 15 day period. (c) Longitudinal analysis of luciferase silencing in 4T1-LUC breast cancer cells treated with a single administration of either free NPs or porous MPs. The NP treatments were removed after 24 h, while MPs were left in coculture with the cells throughout the experiment to mimic biological residence. Luminescent signal for each treatment group was normalized to that of an analogous treatment containing scrambled negative control RNA substituted for luciferase siRNA.