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. 2019 May 3;12(5):429–442. doi: 10.1007/s12195-019-00571-6

Figure 3.

Figure 3

In vivo retention and release of nanoparticles from PLGA microparticles. In vivo analysis of injection site localization of free NPs, nonporous MP depots, and porous MP depots in BALB/c mice. (a) Relative fluorescence of Alexa Fluor® 647(A647)-labelled dsDNA cargo injected subcutaneously and monitored over 56 days. (b) Relative fluorescence of A647-labelled dsDNA cargo, releasing from an intratumoral injection site over 14 days. The fluorescent efficiency of each mouse was captured by IVIS imaging and was normalized to the respective initial (day 0) fluorescence. (c) Representative IVIS images of mice bearing subcutaneously administered particles containing fluorescent dsDNA (Red). (d) Representative IVIS images of the mice treated intratumorally with particles containing fluorescent dsDNA (Red).