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HO-1 overexpressed MSCs dramatically lower serum markers of kidney injury 48 h after CLP operation. CFU (a), Cr (b), BUN (c) levels in serum were assessed by ELISA analysis in normal mice (sham), non-treated CLP mice, MSC treated CLP mice and HO-1 overexpressed MSCs treated CLP mice. (d) ATN scores were measured in each group. p value: ANOVA. Error bar: SEM.
