Effect of β-adrenergic receptor agonist on the recorded electrical signals. (a) Representative recorded field potential trace using Au MEA. (I) Recorded trace before and after application of the β-adrenergic receptor agonist, isoproterenol. (II) Averaged trace (87 peaks) before (red, −) and after (green, +) isoproterenol application. (b) Representative recorded field potential trace using graphene MEA. (I) Recorded trace before and after application of the β-adrenergic receptor agonist, isoproterenol. (II) Averaged trace (70 peaks) before (red, −) and after (green, +) isoproterenol application. Green arrow represents the addition of drug.