Table 1.
Occupancy rates of interactions between α4 and tubulin, the average distance between interacting atoms and the corresponding distance in the crystal structures.
| Interactions between α4 and tubulin: occupancy rate (average distance) (distance in crystal structures) | |||
|---|---|---|---|
| Interacting residues | Apo state | ATP-binding state | ADP-binding state |
| Leu248–Thr109 (α-tubulin) | 100% (5.21 Å) (5.09 Å) | 96.94% (6.53 Å) (7.48 Å) | 0% (14.59 Å) (null) |
| Leu248–Tyr108 (α-tubulin) | 100% (6.76 Å) (5.65 Å) | 100% (5.12 Å) (6.55 Å) | 6.37% (11.25Å) (null) |
| Leu248–Lys112 (α-tubulin) | 99.75% (6.78 Å) (6.21 Å) | 95.15% (7.17 Å) (4.88 Å) | 32.32% (10.02 Å) (null) |
| Lys252–Glu411 (α-tubulin) | 92.95% (6.04 Å) (4.99 Å) | 99.98% (5.12 Å) (4.65 Å) | 0% (16.15 Å) (null) |
| Asn255–Gly412 (α-tubulin) | 98.94% (3.10 Å) (3.63 Å) | 63.44% (3.85Å) (3.52 Å) | 0% (12.39 Å) (null) |
| Ser259–Glu415 (α-tubulin) | 26.40% (6.43 Å) (4.05 Å) | 84.96% (3.93 Å) (5.29 Å) | 12.27% (7.40 Å) (null) |
| Glu270–Lys401 (α-tubulin) | 84.35% (6.72 Å) (8.20 Å) | 95.53% (5.65 Å) (8.01 Å) | 91.44% (5.62 Å) (null) |
| Asn263–Arg402 (α-tubulin) | 63.73% (6.42 Å) (6.23 Å) | 98.47% (4.92 Å) (6.13 Å) | 26.57% (7.40 Å) (null) |