Increased adverse cardiovascular outcomes and high associated costs. For the 25,000 people currently in solitary confinement in US supermax prisons, a 31% increase in prevalence of hypertension will result in the following additional outcomes over the next 45 years (assuming an average life expectancy of 80 years old and the development of premature hypertension at age 35), compared with their counterparts in the maximum security wing of the same prison who experience less social isolation. Figure 1 contains poor-quality text inside the artwork. Please do not re-use the file that we have rejected or attempt to increase its resolution and re-save. It is originally poor; therefore, increasing the resolution will not solve the quality problem. We suggest that you provide us the original format. We prefer replacement figures containing vector/editable objects rather than embedded images. Preferred file formats are eps, ai, tiff, and pdf. Also, please confirm if it is captured correctly.We attach here the figure in its original format.