Figure 4.

PLS model reveals distinct signaling axes regulating myoblast proliferation and differentiation. (a) PLS model loadings (w*c) for all signaling metrics (gray) and responses (blue) in PC1 and PC3. All response measurements and the most positive and negative signaling metrics in each PC are noted; (b, c) Heatmaps of signaling loadings in PC1 (b) and PC3 (c); (d) Plots of model loadings in PC1 vs. PC3 as in (a), with each phosphoprotein individually highlighted (black). Early and late AUC metrics excluded due to redundancy. Trajectory of time-points for select phosphoproteins overlaid by red arrow.