Figure 5.
MTT assay performed on TNBC HCC-1806 and non-TNBC ER (+) MCF-7 cells. Cells were incubated for 48 h before performing the MTT assay. (a) Comparison of IC50 for HCC-1806 and MCF-7 cells when being treated with NfF-kB modulator PTX, STAT3 modulator Nif and Topo-II modulator Am as individual drugs or in triple combination of PTX + Nif + Am solubilized in DMSO. (b) Combinatorial index (CI) calculation on triple drug mixture compared to individual drugs as found to be at least two times more responsive for TNBC HCC-1806 cells compared to non-TNBC MCF-7 cells.