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. 2019 Mar 27;12(3):227–254. doi: 10.1007/s12195-019-00569-0

Figure 13.

Figure 13

Dense ECM and reduced hydraulic conductivity gives increased detachment of clusters. The same case as in Fig. 9 but where we have accounted for tumor cell sensitivity to the reduced conductivity by also increasing cell–fluid interaction setting k^=15. This gives rise to upstream migration generated by fluid stress through uc,fluid-stress as reflected by the negative dip of f^c(αc) in Fig. 11b. (a) Cell volume fraction. (b) Protease distribution. (c) Chemokine distribution. (d) IF pressure Pw. (e) IF velocity uw.