Figure 7.

High IF velocity results in enhanced metastatic behavior. (a) The main effect of increasing the IF flow is a stronger accumulation of tumor cells in the core combined with finger like migration pattern quite similar to that seen in Fig. 2a but with more distinct, slimmer fingers and in fact a full detachment of the outgoing clusters from the primary tumor. (b) Protease distribution. (c) The chemokine distribution shows that the high IF velocity leads to accumulation of some chemokines in the center of primary tumor, in addition to the peritumoral concentration gradients, which should then give rise to an additional chemotactic driven cell migration directed inwardly against the flow. (d) The higher vascular pressure ${\tilde{P}}_{\text{v}}^{\ast }$ gives rise to a higher and more distinct IF pressure profile $P_{\text{w}}$ compared to the base case Fig. 2d. (e) This results also in a considerably higher IF velocity at the tumor margin.