Figure 9.

Dense ECM and reduced hydraulic conductivity gives increased detachment of clusters. (a) A direct consequence of reduced permeability is considerably more aggressive cell migration in the sense that clusters have effectively migrated with the flow and more completely broken loose from the primary tumor. (b) Protease distribution. (c) Chemokine gradients are formed at the rim of the primary tumor as well as further away in the peritumoral region. (d) The reduced permeabiliy (conductivity) gives rise to a higher IF pressure $P_{\text{w}}$ in the tumor region but (e) a lower IF velocity ${\mathbf{u}}_{\text{w}}$ which now takes place more locally between tumor margin and nearby lymphatics.