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. 2018 Nov 28;12(1):15–32. doi: 10.1007/s12195-018-00562-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Schematic of the MB, layer by layer (upper panel), showing the different layers with potential for multimodal imaging. The layer characteristics of the MBs are listed (MB diameter 3.7 µm in hydrated state as measured by AFM). MBs can be coupled to different antibodies via a streptavidin–biotin linkage (lower left panel). TEM (lower right panel) image of a MB with two layers of SPIONs as used in this study.