Figure 1.

HMGB1 levels in critically ill patients. A, HMGB1 plasma concentrations are significantly elevated in critically ill patients compared with healthy controls. B, HMGB1 levels do not differ between intensive care unit (ICU) patients with or without sepsis. C, High disease severity, as defined by an APACHE‐II score above 10, is not associated with elevated plasma HMGB1. D, The need of mechanical ventilation was not associated with HMGB1 levels at ICU admission. P‐values (U‐test) are given in the figure. HMGB1, high mobility group box 1