Table 3.
Multivariate Cox regression analysis of tertiles of B2M for mortality, dialysis, and MIA syndrome
| β coefficient | SE | Hazard ratio | 95% CI | P value | |
|---|---|---|---|---|---|
| All cause mortality (n = 29) | |||||
| Lowest tertile | – | – | 1 (reference) | 1 (reference) | (reference) |
| Middle tertile | 1.64 | 0.86 | 5.18 | 0.95–28.23 | 0.057 |
| Highest tertile | 3.06 | 1.20 | 21.52 | 2.06–225.05 | 0.010a |
| Commencing dialysis (n = 7) | |||||
| Lowest tertile | – | – | 1 (reference) | 1 (reference) | (reference) |
| Middle tertile | 2.30 | 1.86 | 9.90 | 0.26–385.90 | 0.217 |
| Highest tertile | 5.00 | 2.44 | 149.60 | 1.25–1786.63 | 0.004a |
| Commencing dialysis or mortality (n = 35) | |||||
| Lowest tertile | – | – | 1 (reference) | 1 (reference) | (reference) |
| Middle tertile | 1.75 | 0.73 | 5.78 | 1.38–24.27 | 0.016a |
| Highest tertile | 3.25 | 1.00 | 25.91 | 3.63–184.58 | <0.001a |
| Cardiovascular event (n = 27) | |||||
| Lowest tertile | – | – | 1 (reference) | 1 (reference) | (reference) |
| Middle tertile | 2.19 | 0.84 | 8.93 | 1.61–49.31 | 0.012a |
| Highest tertile | 4.36 | 1.17 | 65.84 | 6.33–684.26 | <0.001a |
| MIA score = 3 (n = 22) | |||||
| Lowest tertile | – | – | 1 (reference) | 1 (reference) | (reference) |
| Middle tertile | 2.48 | 1.04 | 11.94 | 1.54–92.29 | 0.017a |
| Highest tertile | 5.03 | 1.39 | 152.50 | 9.96–2335.20 | <0.001a |
B2M, β2 microglobulin; MIA, malnutrition, inflammation, and atherosclerosis; SE, standard error.
Adjusted for age, gender, BMI, underlying disease (DM, hypertension), eGFR, serum albumin, hemoglobin, uric acid, HbA1c, C‐reactive protein, LDL‐cholesterol, calcium, and phosphate at baseline.
a
P < 0.05.