Table 3.
Comparison in percent reductions of TC and non‐HDL between carriers and noncarriers of the 6 gene variants
| Gene variants | Carriers (n) Noncarriers (n) P value | %C TC | %C non‐HDL |
|---|---|---|---|
| APOE2 c.526C > T | NC (CC, n = 95) | −23.8 (−63.6; 19.3) | −28.6 (−70.5; 27.3) |
| C (n = 5) | −24.5 (−40.5; −17.6) | −28.6 (−37.3; 23.4) | |
| P | .524 | .554 | |
| APOE4 c.388T > C | NC (TT, n = 77) | 23.8 (−27.5; −20.2) | −28.7 (−33.5; −24.0)† |
| C (n = 23) | −21.1 (−27.8; −14.3) | −27.3 (−35.7; −18.8)† | |
| P | .585 | .955 | |
| SLCO1B1 c.521T > C | NC (TT, n = 68) | −23.2 (−27.1; −19.4) | −28.0 (−32.9; −23.1)† |
| C (n = 32) | −23.1 (−28.6; −17.6) | −29.2 (−36.6; −21.8)† | |
| P | .914 | .845 | |
| CYP3A4 c.‐392G > A | NC (CC, n = 67) | −23.6 (−27.6; −19.7) | −29.3 (−34.4; −24.2)† |
| C (n = 2) | −44.8 and −20.7 | −53.4 and −29.0 | |
| P | .512 | .397 | |
| HMGCR c.1564‐106A > G | NC (AA, n = 27) | −28.3 (−33.5; −23.1) | −34.9 (−41.7; −28.1)† |
| C (n = 73) | −21.6 (−25.5; −17.7) | −26.4 (−31.5; −21.3)† | |
| P | .098 | .097 | |
| LPA c.3947 + 467T > C | NC (TT, n = 77) | −23.1 (−27.0; −19.2) | −27.3 (−32.4; −22.3)† |
| C (n = 23) | −20.9 (−26.9; −15.0) | −29.9 (−37.9; −22.0)† | |
| P | .752 | .380 |
†cases normally distributed.
C, carriers; %C, percentage change; NC, noncarriers; non‐HDL, non‐HDL cholesterol; P, associated probability; TC, total cholesterol.