Table 3.
Risk of CAD according to +45T>G and +276 G>T polymorphisms in cases and controls
| Unadjusted | Adjusted | ||||
|---|---|---|---|---|---|
| Genotype | OR (95% CI) | P | OR (95% CI) | P | |
| +276 G>T (rs1501299) | |||||
| Additive model GG vs GT,TT | GG vs GT | 0.9 (0.53‐1.51) | .90 | 1.04 (0.37‐2.88) | .90 |
| GG vs TT | 1.1 (0.66‐1.86) | .69 | 0.96 (0.34‐2.66) | .93 | |
| Dominant model (GG vs GT+TT) | GG vs GT + TT | 1.01 (0.72‐1.41) | .94 | 0.47 (0.22‐0.97) | .04 |
| Recessive model (GG+GT vs TT) | GG + GT vs TT | 1.09 (0.68‐1.74) | .7 | 0.64 (0.25‐1.60) | .34 |
| +45 T>G (rs2241766) | |||||
| Additive model (TTvs TG, GG) | TT vs TG | 1.22 (0.60‐2.49) | .57 | 2.21 (0.48‐10.16) | .30 |
| TT vs GG | 0.81 (0.40‐1.66) | .72 | 1.38 (0.33‐5.76) | .3 | |
| Dominant TT vs TG+GG | TT vs TG + GG | 0.9 (0.63‐1.28) | .56 | 2.59 (1.17‐5.70) | .01 |
| Recessive TT+TG vs GG | TT+TG vs GG | 0.78 (0.40‐1.50) | .46 | 0.96 (0.24‐3.89) | .96 |
Unadjusted univariate logistic regression analysis.
Adjusted multivariate logistic regression analysis after adjustment for confounders.
Confounders used for this analysis: hypertension, diabetes, age, sex, smoking, BMI, triglyceride, and cholesterol.