Table 2.
Comparison of different genotypes of SMAD‐7 gene in different groups
| Variables | Cases (n=86) | Controls (n=36) | P‐value | Sig. |
|---|---|---|---|---|
| No. (%) | No. (%) | |||
| TT (mutant) | 29 (33.7) | 8 (22.2) | .3 | NS |
| CT (heterozygote) | 44 (51.2) | 15 (41.7) | .4 | NS |
| CC (wild) | 13 (15.1) | 13 (36.1) | .01 | S |
| T allele | 102 (59.3) | 31 (43.1) | .02 | S |
| C allele | 70 (40.6) | 41 (56.9) | .02 | S |
| Variables | Colon (n=68) | Rectal (n=18) | P‐value | Sig. |
|---|---|---|---|---|
| No. (%) | No. (%) | |||
| TT (mutant) | 19 (27.9) | 10 (55.6) | .04 | S |
| CT (heterozygotes) | 39 (57.4) | 5 (27.8) | .03 | S |
| CC (wild) | 10 (14.7) | 3 (16.7) | .9 | NS |
Table shows that the wild genotype CC is common in controls. On the other hand the heterozygotes genotype is prominent in colon cancer while the mutant type is common in rectal cancer. S, significant; NS, non significant.