Table 1.
Parameters | Patients (n) | Circulating mRNA levels | P value | |
---|---|---|---|---|
Mean | P25, P75 | |||
Gender | ||||
Female | 25 | 0.109 743 561 | 0.091 742 722, 0.140 931 388 | .322 |
Male | 58 | 0.097 293 03 | 0.065 395 301, 0.125 066 853 | |
Age | ||||
<60 | 26 | 0.099 724 859 | 0.0657 648 44, 0.130 175 587 | .878 |
≥60 | 57 | 0.101 644 534 | 0.073 990 558, 0.136 786 893 | |
Position | ||||
Colon | 45 | 0.116 346 148 | 0.097 555 575, 0.139 118 238 | .006a |
Rectum | 38 | 0.082 921 266 | 0.032 337 544, 0.105 247 53 | |
Position | ||||
Left | 55 | 0.092 575 405 | 0.0597 328 11, 0.124 199 426 | .011a |
Right | 28 | 0.117 676 339 | 0.096 030 901, 0.141 137 55 | |
Differentiation | ||||
Low | 15 | 0.097 151 658 | 0.080 429 096, 0.124 199 426 | .692 |
Middle + High | 66 | 0.103 157 112 | 0.067 057 415, 0.137 884 661 | |
Tumor size (cm) | ||||
<5 | 56 | 0.102 646 83 | 0.068 168 753, 0.138 425 668 | .961 |
≥5 | 24 | 0.103 273 861 | 0.072 744 688, 0.121 528 341 | |
T stage | ||||
T1 + T2 | 8 | 0.086 534 894 | 0.039 638 599, 0.135 736 415 | .380 |
T3 + T4 | 73 | 0.103 656 138 | 0.072 343 228, 0.136 786 893 | |
Lymph node | ||||
Negative | 48 | 0.0967 132 19 | 0.068 168 753, 0.124 474 066 | .285 |
Positive | 33 | 0.109 360 099 | 0.072 343 228, 0.139 562 53 | |
Metastasis | ||||
Negative | 63 | 0.099 118 668 | 0.065 429 811, 0.136 543 291 | .351 |
Positive | 19 | 0.111 820 784 | 0.072 765 432, 0.137 030 495 | |
AJCC stage | ||||
1 + 2 | 39 | 0.095 395 084 | 0.065 291 769, 0.124 207 830 | .283 |
3 + 4 | 42 | 0.107 874 035 | 0.072 554 330, 0.137 968 207 | |
Nerve infiltration | ||||
Negative | 61 | 0.093 331 443 | 0.065 584 145, 0.123 324 789 | .004a |
Positive | 18 | 0.133 5957 48 | 0.090 526 172, 0.143 513 707 | |
Vascular invasion | ||||
Negative | 44 | 0.091 363 932 | 0.060 442 372, 0.124 205 729 | .048a |
Positive | 35 | 0.114 544 887 | 0.080 429 096, 0.139 582 078 | |
MSI | ||||
Negative | 11 | 0.156 564 993 | 0.097 856 934, 0.232 692 177 | .022a |
Positive | 49 | 0.094 413 756 | 0.065 584 145, 0.137 384 986 | |
Chemotherapy | ||||
No | 66 | 0.102 621 82 | 0.071 735 88, 0.137 884 661 | .591 |
Yes | 17 | 0.094 914 391 | 0.063 318 757, 0.110 674 8 | |
CEA | ||||
<5 | 45 | 0.095 849 921 | 0.065 360 79, 0.124 203 628 | .327 |
≥5 | 38 | 0.107 193 114 | 0.072 554 33, 0.139 787 002 | |
CA199 | ||||
<37 | 62 | 0.093 464 516 | 0.064 270 753, 0.124 296 575 | .022a |
≥37 | 21 | 0.123 418 323 | 0.077 289 948, 0.141 579 124 |
MSI, microsatellite instability; CRC, colorectal cancer; HMGA2, high mobility group AT‐hook 2.
P < .05, statistical significance.