Table 3.

Comparison of the ADO rates between the two WGA methods using SNP alleles

WGA method	Cell types	Number of tested SNP sites	Number of detected SNP sitesa	ADO in detected SNP sites	ADO rateb (%)
MALBAC	1 cell (fibroblast)	112	96 (85.71%)	6	6.25
	2 cells (fibroblasts)	112	91 (81.25%)	3	3.30
	5 cells (fibroblasts)	112	109 (97.32%)	1	0.92
MDA	1 cell (fibroblast)	112	108 (97.62%)	10	9.26
	2 cells (fibroblasts)	112	104 (92.86%)	9	8.65
	5 cells (fibroblasts)	112	112 (100.00%)	0	0.00

SNP amplification efficiencies between the MALBAC and MDA methods for single‐cell groups: χ ²=7.906, P=.004; two‐cell groups; χ ²=6.694, P=.010; and five‐cell groups: χ ²=3.041, P=.081. The ADO rates in each cell‐type group did not differ significantly.

Significance (P value) evaluation between the MALBAC and MDA groups: ^aTotal SNP amplification rate; ^bThe total ADO rate. Chi‐square test (SPSS software, Chicago, IL, USA) data: ^a χ ²=16.341, P=.000; ^b χ ²=2.144, P=.143.