Table 2.
Agreement between direct and standardized susceptibility testing methods
| Etest | Broth microdilution | Disk diffusion | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Categorical agreement (n) | Essential agreement | Categorical agreement (n) | Essential agreement | Categorical agreement (n) | CC | P | |||||||||||||||
| Antifungals | VME | ME | MiE | SD | NSD | (%) | CC | P | VME | ME | MiE | SD | NSD | (%) | CC | P | VME | ME | MiE | ||
| Fluconazole | 0 | 0 | 5 | 95.2 | 0.786 | <.001 | 0 | 0 | 0 | 100 | 0.913 | <.001 | 0 | 0 | 5 | 0.931 | <.001 | ||||
| Voriconazole | 0 | 1 | 3 | 95.2 | 0.996 | <.001 | 0 | 1 | 5 | 100 | 0.897 | <.001 | 0 | 2 | 6 | 0.889 | <.001 | ||||
| Posaconazole | 1 | 5 | 90.3 | 0.910 | <.001 | 0 | 1 | 98.4 | 0.998 | <.001 | |||||||||||
| Caspofungin | 5 | 0 | 13 | 87.1 | 0.776 | <.001 | 0 | 0 | 2 | 93.5 | 0.589 | <.001 | |||||||||
| Anidulafungin | 0 | 0 | 5 | 96.8 | 0.591 | <.001 | 0 | 0 | 0 | 100 | 0.936 | <.001 | |||||||||
| Amphotericin B | 0 | 0 | 100 | 0.992 | <.001 | 0 | 1 | 98.4 | 0.578 | <.001 | |||||||||||
VME, very major errors; ME, major errors; MiE, minor errors; SD, substantial differences; NSD, nonsubstantial differences; CC, paired samples correlation coefficients between direct and standardized methods; P values of ≤.05 indicate significant agreement.