Table 3.

Agreement of direct and standardized susceptibility testing methods with reference broth microdilution method

Antifungals	Etest (direct and standardized)																Disk diffusion (direct and standardized)
	Categorical agreement (n)										Essential agreement (%)		CC		P		Categorical agreement (n)						CC		P
	VME		ME		MiE		SD		NSD		DT	ST	DT	ST	DT	ST	VME		ME		MiE		DT	ST	DT	ST
	DT	ST	DT	ST	DT	ST	DT	ST	DT	ST							DT	ST	DT	ST	DT	ST
Fluconazole	0	0	0	0	4	7					79.0	77.4	0.765	0.510	<.001	<.001	0	0	1	1	6	2	−0.695	−0.734	<.001	<.001
Voriconazole	0		1	2	15	10					77.4	85.5	0.896	0.898	<.001	<.001	0	0	2	0	4	4	−0.458	−0.492	<.001	<.001
Posaconazole							5	7	15	7	67.7	77.4	0.614	0.613	<.001	<.001
Caspofungin	0	0	0	6	9	17					74.2	50.0	0.489	0.361	<.001	.004
Anidulafungin	0	0	1	0	2	5					67.7	83.9	0.505	0.709	<.001	<.001
Amphotericin B							7	7	9	11	74.2	71.0	0.432	0.423	<.001	.001

VME, very major errors; ME, major errors; MiE, minor errors; SD, substantial differences; NSD, nonsubstantial differences; CC paired samples correlation coefficients between direct/standardized Etest/disk diffusion and reference methods; P values of ≤.05 indicate significant agreement.