Table 6.

Validations of reference intervals of SII, PLR, NLR, LMR and MLR in a cohort of 450 healthy persons

Item	Stratification	RIs	n	Range of validation data	Number of below the down‐limit	Number of above the upper‐limit	Number of outsider	OR
SII	no	[161, 701]	450	[140, 1147]	8	27	35	0.0778
PLR	Aged 18‐65	[61, 179]	235	[53, 284]	2	12	14	0.0596
	Aged more than 65	[55, 179]	215	[44, 264]	3	11	14	0.0651
NLR	Male aged 18‐65	[0.90, 2.94]	113	[1.07, 4.06]	0	8	8	0.0708
	Female aged 18‐65	[0.85, 3.06]	122	[1.03, 5.14]	0	5	5	0.0410
	Male aged more than 65	[0.95, 3.57]	108	[1.04, 4.29]	0	4	4	0.0370
	Female aged more than 65	[0.83, 3.30]	107	[1.00, 5.24]	0	6	6	0.0561
LMR	Male aged 18‐65	[2.50, 7.50]	113	[2.67, 9.50]	0	6	6	0.0531
	Female aged 18‐65	[2.75, 8.50]	122	[1.17, 9.00]	3	2	5	0.0410
	Male aged more than 65	[2.16, 7.41]	108	[1.29, 8.67]	5	3	8	0.0741
	Female aged more than 65	[2.40, 8.33]	107	[1.29, 10.50]	2	7	9	0.0841
MLR	Male aged 18‐65	[0.12, 0.35]	113	[0.11, 0.38]	1	5	6	0.0531
	Female aged 18‐65	[0.10, 0.32]	122	[0.11, 0.86]	0	5	5	0.0410
	Male aged more than 65	[0.12, 0.41]	108	[0.12, 0.78]	0	9	9	0.0833
	Female aged more than 65	[0.11, 0.33]	107	[0.10, 0.78]	1	5	6	0.0561

n, sample number; RIs, reference intervals; OR, outsider‐rate.

RIs validated with outsider‐rate <0.10 (OR<0.10) is considered efficient and successfully established.