Table 2.
The genotype distribution of three SNPs in none‐LD group and LD group
| Gene | Genotype | LD group (n=41) | None‐LD group (n=79) | P valuea | Raw OR (95% CI) | P valueb | Adjusted OR (95% CI) |
|---|---|---|---|---|---|---|---|
| GPR174 | rs3827440 | ||||||
| TT | 23 | 34 | Ref. | Ref. | Ref. | Ref. | |
| TC | 12 | 28 | .296 | 0.63 (0.27‐1.50) | .002 | 0.13 (0.04‐0.48) | |
| CC | 6 | 17 | .230 | 0.52 (0.18‐1.53) | .018 | 0.12 (0.02‐0.69) | |
| TC+CC | 18 | 45 | .276 | 0.59 (0.28‐1.27) | .007 | 0.24 (0.08‐0.67) | |
| T | 58 | 96 | Ref. | Ref. | Ref. | Ref. | |
| C | 24 | 62 | .127 | 0.64 (0.36‐1.50) | .004 | 0.31 (0.14‐0.68) | |
| PTPN22 | rs3789604 | ||||||
| AA | 16 | 47 | Ref. | Ref. | Ref. | Ref. | |
| AC | 13 | 28 | .483 | 1.36 (0.57‐3.25) | .315 | 1.80 (0.57‐5.69) | |
| CC | 12 | 4 | <.001 | 8.81 (2.49‐31.25) | <.001 | 35.15 (5.41‐228.56) | |
| AC+CC | 25 | 32 | .033 | 2.30 (1.06‐4.97) | .028 | 3.09 (1.13‐8.47) | |
| A | 45 | 122 | Ref. | Ref. | Ref. | Ref. | |
| C | 37 | 36 | <.001 | 2.79 (1.57‐4.94) | <.001 | 5.82 (2.66‐12.77) | |
| RNASET2 | rs9355610 | ||||||
| GG | 27 | 20 | Ref. | Ref. | Ref. | Ref. | |
| GA | 12 | 41 | <.001 | 0.22 (0.09‐0.52) | <.001 | 0.10 (0.03‐0.31) | |
| AA | 2 | 18 | <.001 | 0.08 (0.02‐0.40) | .007 | 0.09 (0.02‐0.52) | |
| GA+AA | 14 | 59 | <.001 | 0.18 (0.08‐0.40) | <.001 | 0.17 (0.07‐0.42) | |
| G | 66 | 81 | Ref. | Ref. | Ref. | Ref. | |
| A | 16 | 77 | <.001 | 0.26 (0.14‐0.48) | <.001 | 0.25 (0.13‐0.50) |
GD, Graves’ disease; LD, Liver damage; OR, Odds ratios; CI, Confidence interval; Ref., Reference.
a
P value for raw OR.
b
P value for adjusted OR.