Figure 1 – Sex- and treatment-specific trends in serum potassium, creatinine, and systolic blood pressure.

Compared to spironolactone was associated with significant increases in serum potassium and creatinine as well as decrease in systolic blood pressure in both men and women. In women there was a significantly greater increase in creatinine at 4 months (p_interaction=0.03) and serum potassium at 12 months (p_interaction=0.04).