Table 3a –

Baseline patient characteristics in TOPCAT (placebo arm only), I-PRESERVE, and DIG-PEF

Characteristic	TOPCAT	I-PRESERVE	DIG
Age	↑	↑	↑
LVEF	↑	↑	↑
Atrial fibrillation	↓	↓	Sinus only
Coronary artery disease	↓	↓	↓
Hypertension	↓	↓	↓
Diabetes mellitus	↓	↔	↑
Body mass index	↑	↑	↑
Tobacco use	↓	↓	NA
COPD	↓	↓	NA
Heart rate	↑	↑	NA
Systolic blood pressure	↑	↑	↑
Estimated GFR	↓	↓	↓
Hemoglobin	↓	↓	↓
NYHA class	↑	↑	↑
MLWHF/KCCQ	⇑	⇑	NA

^↑- Significantly higher in women

^↓- Significantly lower in women

^↔- No significant sex difference

^⇑- Significantly Higher MLWHF/lower KCCQ in women