Table 3b –
Comparison of event rates TOPCAT (placebo arm only), CHARM-Preserved, I-PRESERVE and DIG trials, events/100 patient years (5, 16, 32)
| TOPCAT | CHARM-Preserved | I-PRESERVE | DIG-PEF* | |||||
|---|---|---|---|---|---|---|---|---|
| Women | Men | Women | Men | Women | Men | Women | Men | |
| Outcome | n=440 | n=441 | n=1811 | n=1212 | n=2491 | n=1637 | n=341 | n=378 |
| Deaths | ||||||||
| All-cause | 3.64 | 4.15 | 5.68 | 5.3 | 4.32 | 6.72 | 7.88 | 8.07 |
| CV | 2.15 | 2.68 | 3.83 | 3.87 | 2.51 | 4.21 | 5.96 | 5.62 |
| Non-CV | 0.93 | 1.2 | 1.84 | 1.43 | 1.26 | 2.14 | 1.84 | 1.59 |
| Hospitalization | ||||||||
| CV | 6.34 | 6.8 | 20.4 | 20.4 | 17 | 21.8 | 15.2 | 17 |
| HF | 3.79 | 4.43 | 7.32 | 5.75 | 7.1 | 7.8 | 5.26 | 8.53 |
| Non-CV | 6.91 | 7.42 | 19.3 | 14.9 | 14.1 | 17.5 | 15.3 | 13.1 |
CV = Cardiovascular HF = Heart failure
*
Event rates derived from DIG trial data obtained from BioLINCC