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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: FEBS Lett. 2019 Oct 15;593(20):2853–2867. doi: 10.1002/1873-3468.13619

Figure 1. Illustrations of normal and abnormal origin licensing outcomes.

Figure 1.

A. Normal origin licensing and CDK2-dependent firing in G1 and S phase. B. Unscheduled licensing and firing leading to re-replication and genome instability. C. Underlicensing in G1 leading to replication stress and genome instability.