Figure 6. Correlations between cardiac function, myocardial injury and cytokine expression in Dsg2^mut/mut mice. A.

Pearson’s correlation between cardiac function (ejection fraction) and myocardial fibrosis in Dsg2^mut/mut mice treated with Bay 11–7082 (showing responders and non-responders). B. Pearson’s correlation between cardiac function (ejection fraction) and myocardial apoptosis in Dsg2^mut/mut mice treated with Bay 11–7082 (showing responders and non-responders). C. Pearson’s correlation between cardiac function (ejection fraction) and myocardial fibrosis in vehicle-treated WT and Dsg2^mut/mut mice, and Dsg2^mut/mut mice treated with Bay 11–7082. D. Pearson’s correlation between cardiac function (ejection fraction) and myocardial apoptosis in vehicle-treated WT and Dsg2^mut/mut mice, and Dsg2^mut/mut mice treated with Bay 11–7082. E, F. Pearson’s correlation between expression levels of LIX (Panel E) and OPN (Panel F) and ejection fraction in each animal in all cohorts (vehicle-treated WT and Dsg2^mut/mut mice, and Dsg2^mut/mut mice treated with Bay 11–7082). Data in panels A-D are shown as mean ± SEM; n=10 for vehicle-treated WT mice; n=9 for vehicle-treated Dsg2^mut/mut mice; and n=17 for Dsg2^mut/mut mice treated with Bay 11–7082. Data in panels E, F are shown as mean ± SEM; n=5 for vehicle-treated WT and Dsg2^mut/mut mice; n=8 for Dsg2^mut/mut mice treated with Bay 11–7082. All correlation coefficients (r) and p-values were calculated using two-tailed Pearson’s correlation analysis.