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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Stroke. 2019 Oct 18;50(11):3045–3050. doi: 10.1161/STROKEAHA.119.025376

Table 2.

Association of Metabolic Syndrome Components with Ischemic Stroke in Participants with Atrial Fibrillation, Atherosclerosis Risk in Communities (ARIC) Study

Individual variables Absent HR (95% CI), Model 1 P-value HR (95% CI), Model 2 P-Value HR (95% CI), Model 3 P-Value
High Waist Circumference 1 (Ref) 0.95 (0.64–1.42) 0.81 0.84 (0.56–1.27) 0.41 0.81 (0.55–1.25) 0.37
High Triglycerides 1 (Ref) 1.33 (0.92–1.94) 0.13 1.22 (0.83–1.80) 0.31 1.20 (0.82–1.77) 0.36
Low HDL 1 (Ref) 1.58 (1.07–2.34) 0.02 1.48 (0.99–2.21) 0.06 1.47 (0.99–2.20) 0.06
Elevated blood pressure 1 (Ref) 1.35 (0.83–2.20) 0.23 1.28 (0.77–2.12)* 0.34 1.24 (0.75–2.05)* 0.40
Elevated fasting plasma glucose 1 (Ref) 1.18 (0.79–1.77) 0.42 1.13 (0.75–1.71)** 0.55 1.12 (0.75–1.69)** 0.58

Model 1: Cox proportional hazards model adjusted for age, sex, race/center

Model 2: Cox proportional hazards model adjusted for age, sex, race/center and the remaining CHA2DS2-VASc

variables of stroke/transient ischemic attack, heart failure, hypertension, diabetes,

myocardial infarction, peripheral artery disease and also anticoagulation use.

Model 3: Cox proportional hazards model adjusted for age, sex, race/center and the remaining CHADS2

variables of stroke/transient ischemic attack, heart failure, hypertension, diabetes and also anticoagulation use.

Ref indicates reference and HDL, High-density lipoprotein.

Ref for prehypertension includes participants without prehypertension or HTN

Ref for prediabetes includes participants without prediabetes or diabetes

*

Not adjusted for hypertension

**

Not adjusted for diabetes