Figure 5. Extracellular pH measurements in TRAMP tumors via hyperpolarized [¹³C] bicarbonate imaging suggest extracellular acidification is associated with high-grade disease.

(A) Representative overlays of extracellular pH measured with hyperpolarized [¹³C] bicarbonate for the mice displayed in Figure 2. (B–C) Scatter plots demonstrating significant differences in pH metrics obtained from HP ¹³C images between low- and high-grade regions over all mice: (B) mean; and (C) regional-minimum (n = 5 low-grade, n = 7 high-grade). *p < 0.05.