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. 2019 Oct 22;10(58):6152–6167. doi: 10.18632/oncotarget.27247

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Copyright: © 2019 Pourmaleki et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) A CK7 positive/CK20 negative in situ EMPD case shows strong staining intensity (3) in all tumor cells (4). (B) A CK20 positive/CK7 negative in situ EMPD case shows strong staining intensity (3) in all tumor cells (4). (C and D) A CK7 positive/CK20 positive in situ EMPD case shows weak staining intensity (1) in all tumor cells (4) for both markers. (E and F) A CK7 positive/CK20 positive invasive EMPD case shows a strong staining intensity (3) in all tumor cells (4) for CK7 and a weak staining intensity (1) in all tumor cells (4) for CK20. (G) Coexpression of CK7 and CK20 for all tumors with an in situ component (n = 49) categorized by sex, extent of disease (E o D.), origin, and site. (H) Coexpression of CK7 and CK20 for all tumors with an invasive component (n = 21) categorized by sex, extent of disease (E. o. D.), origin, and site.