Figure 3. Hierarchical clustering of in situ and invasive EMPD.

Hierarchical clustering of all immunohistochemical scores and tumor characteristics (CD8 density (cell/mm²), sex, site, origin, extent of disease (E. o. D.), and treatment) of all tumors with an in situ component (n = 49) (A) and all tumors with an invasive component (n = 21) (B). The patient numbers are listed below the heatmap. Any patient number followed by a/b distinguishes between multiple resections from the same patient. Missing values are labeled as NA and not utilized in the clustering.