Figure 4. Hierarchical clustering of in situ and invasive components of the same tumor and multiple longitudinal resections.

Hierarchical clustering of all immunohistochemical scores and tumor characteristics (CD8 density (cell/mm²), sex, site, origin, extent of disease (E. o. D.), treatment, and component (comp.)) of all tumors with both an in situ and invasive component (n = 16) (A) and all patients with two resections (n = 6) (B). Case a represents an older resection while cases b represents the more recent resection for patients with two resections. Missing values are labeled as NA and not utilized in the clustering.