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FLT3 is shown in light blue, the activation loop is shown in magenta, and the juxtamembrane domain is shown in blue. (A) Overall structure. (B) Binding mode of gilteritinib. Hydrogen bonds are shown as dashed lines. (C) Overlay with the c-Kit active structure (PDB 1PKG). c-Kit is shown in purple. DFG motifs are shown as a stick model.
