Table 3.

Tumor responses.

Responses	All patients (n = 104) [n or %]	BBM (n = 40) [n or %]	Non-BBM (n = 64) [n or %]
CR	0 (0.0)	0	0
PR	86 (82.7)	34 (85.0)	52 (81.3)
SD	16 (15.4)	6 (15.0)	10 (15.6)
PD	2 (1.9)	0	2 (3.1)
ORR	82.7% [95% CI, 75–90%]	85.0%*	81.3%
DCR	98.1% [95% CI, 95–101%]	100%**	96.9%

^*P = 0.791 vs. Non-BBM.

^**P = 0.522 vs. Non-BBM.

CR, complete response; DCR, disease control rate; ORR, objective response rate; PD, progressive disease; PR, partial response; SD stable disease; BBM, baseline brain-metastases; Non-BMM, without baseline brain-metastases.