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Minocycline ameliorated the levels of IL-1β, IL-6, TNF-α, HMGB1, and netrin-1 in the serum of GCI mice. Mice were treated with minocycline or saline after GCI surgery, and the serum was collected for ELISA analysis. (A–E) show the statistical results of the above inflammatory factors successively. (*p < 0.05, **p < 0.01, ***p < 0.001 compared with GCI + NS, n = 10).
