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. 2019 Sep 26;105(4):773–787. doi: 10.1016/j.ajhg.2019.09.001

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Cross-ancestry Comparison of Colocalized GWAS-eQTL Signals

Locus plots showing the regional associations for BMI in Japanese individuals,⁶¹ colored by East Asian LD (EAS) (top) and gene expression in Finns (bottom), colored by Finnish LD.

(A) A DAP3 eQTL signal is colocalized with a BMI signal near GON4L. The lead variant is shared between the GWAS and eQTL studies and the patterns of association are similar.

(B) A SULT1A2 eQTL signal is colocalized with a BMI signal near IL27/NUPR1. The LD between the lead eQTL and GWAS variants is low in East Asians (r² = 0.22) but high in Finns (r² = 0.93).