Table 1.
Primary and Secondary eQTLs Colocalized at GWAS Loci
| Primary Signals | Secondary Signals | ||||||
|---|---|---|---|---|---|---|---|
| Trait | GWAS Signals Associated with ≥1 Gene | Colocalized GWAS Signals | Colocalized Genes | Genes (%) for Which the Trait Risk Allele Is Associated with Decreased Expression | Colocalized GWAS Signals | Colocalized Genes | Genes (%) for Which the Trait Risk Allele Is Associated with Decreased Expression |
| BMI | 310 | 85 | 116 | 60 (52%) | 12 | 11 | 4 (36%) |
| All lipids | 186 | 56 | 62 | 31 (50%) | 7 | 7 | 3 (43%) |
| HDL | 73 | 25 | 30 | 18 (60%) | 3 | 3 | 2 (67%) |
| LDL | 64 | 16 | 18 | 8 (44%) | 1 | 1 | 0 (0%) |
| Triglycerides | 42 | 18 | 19 | 11 (58%) | 2 | 2 | 1 (50%) |
| Total cholesterol | 47 | 13 | 13 | 6 (46%) | 2 | 2 | 1 (50%) |
| WHRadjBMI | 157 | 48 | 57 | 35 (61%) | 9 | 9 | 5 (56%) |
| WHR | 134 | 40 | 49 | 32 (65%) | 6 | 6 | 3 (50%) |
| T2D | 115 | 28 | 37 | 20 (54%) | 7 | 8 | 4 (50%) |
| Cardiovascular disease | 28 | 9 | 10 | 6 (60%) | – | – | – |
| Adiponectin | 11 | 4 | 4 | 2 (50%) | – | – | – |
| Any trait | 874 | 231 | 287 | 152 (53%) | 31 | 31 | 15 (48%) |
Colocalized eQTL (FDR < 1%; p < 9.63 × 10−6) among 2,843 GWAS signals (variants clumped by LD r2 > 0.8) associated with one or more of 93 cardiometabolic traits. Each GWAS variant may colocalize with an eQTL for more than one gene. GWAS signals reported for multiple traits are included in counts of colocalized eQTLs for each trait, so signals and genes are not unique by row. Percentages expressed as the number of genes for which the GWAS risk allele was associated with decreased expression among all colocalized genes for that trait. No secondary eQTL signals were found to be colocalized with GWAS loci for cardiovascular disease or adiponectin.