Table 2.

Combined and Sex-Stratified Conditional Association Analyses of HbA1c for the Two Distinct Single Nucleotide Variants in the G6PD Region in Non-Diabetic African-Americans in TOPMed Cohorts

-	-	-	-	Pooled Analysis (n = 3,123)			Conditional Analysis on rs1050828			Males (n = 1,269)			Females (n = 1,854)
MarkerIDa	rsID	Ref/Alt Allele	AAFb	Beta	SE	p Value	Beta	SE	p Value	Beta	SE	p Value	Beta	SE	p Value	Heterogeneity p Valuec
X:154533025	rs76723693	A/G	0.005	−0.44	0.07	2.2E-09	−0.50	0.06	2.8E-15	−0.52	0.12	6.8E-6	−0.33	0.10	6.2E-04	0.19
X:154536002	rs1050828	C/T	0.12	−0.41	0.01	8.4E-205	-	-	-	−0.44	0.02	2.3E-148	−0.37	0.02	2.7E-69	0.008

^aMarkerID is defined as Chromosome: Position. Positions are indicated on Build 38.

^bAAF: Alternate allele frequency

^cHeterogeneity p Value: test of difference in effect sizes between males and females, accounting for the correlation between males and females statistics