Figure 3.

TCA Metabolite Signatures in Individuals with Neurodevelopmental Disorders Compared to Those with Cancer

A general logistic regression model was applied to evaluate the association of metabolite levels in neurodevelopmental disorders (ASD/DD) versus cancer, with age, gender, and genotype as covariates. Heatmap depicts TCA cycle metabolites (top label) and significance of associations relative to various phenotypic and/or genotypic group comparisons (left label). Blue color corresponds to an association with decreased metabolite levels, whereas orange color corresponds to an association with increased metabolite levels. Color intensity corresponds to different thresholds of p value significance (scale on the right).