Table 2.

Summary Statistics from HDiff and HAid GWAS Analysis, at SNPs Highlighted in Previous Adult Hearing Loss GWAS

Variant Highlighted in Previous Study				Summary Statistics from HDiff and HAid Analysis in the UKBB Cohort
Citation	Gene	SNP	CHR	BP	A1	A0	INFO	UKBB Phenotype	A1FREQ	BETA	SE	p
Friedman et al.14	GRM7	rs11928865	3	7155702	T	A	0.989	HDiff	0.741	0.0016	0.0015	0.28
								HAid	0.742	−0.0014	0.0007	0.05
Van Laer et al.12	IQGAP2	rs457717	5	75920972	A	G	0.986	HDiff	0.326	0.0013	0.0014	0.34
								HAid	0.325	−0.0006	0.0007	0.37
	GRM7	rs161927	3	7838242	G	A	0.988	HDiff	0.134	0.0038	0.0019	0.05
								HAid	0.136	−0.0002	0.0009	0.86
Girotto et al.17	DCLK1	rs248626	5	141097725	A	G	1.000	HDiff	0.251	0.0018	0.0015	0.23
								HAid	0.252	−0.0003	0.0007	0.71
	KCNMB2	rs4603971	3	177902467	G	A	0.992	HDiff	0.934	−0.0015	0.0027	0.58
								HAid	0.934	0.0006	0.0012	0.63
	CMIP	rs898967	16	81566780	C	T	0.981	HDiff	0.476	0.0010	0.0013	0.45
								HAid	0.476	0.0002	0.0006	0.76
	GRM8	rs2687481	7	125869122	G	T	0.998	HDiff	0.811	−0.0018	0.0017	0.28
								HAid	0.810	0.0012	0.0008	0.14
Nolan et al.19	ESSRG	rs2818964	1	216682448	G	A	0.978	HDiff	0.366	−0.0015	0.0014	0.27
								HAid	0.366	0.0004	0.0006	0.55
Wolber et al.15	SIK3	rs681524	11	116748314	T	C	0.992	HDiff	0.927	−0.0010	0.0026	0.71
								HAid	0.928	0.0018	0.0012	0.13
Vuckovic et al.16	PCDH20	rs78043697	13	62467039	T	C	0.995	HDiff	0.928	0.0000	0.0025	1.00
								HAid	0.928	0.0010	0.0012	0.38
	SLC28A3	rs7032430	9	86714002	C	A	0.959	HDiff	0.782	−0.0013	0.0016	0.43
								HAid	0.783	−0.0001	0.0008	0.91
Fransen et al.10	ACVR1B	rs2252518	12	52381026	C	A	0.996	HDiff	0.739	−0.0010	0.0015	0.50
								HAid	0.739	0.0001	0.0007	0.85
	CCBE1	rs34175168	18	57180682	G	A	0.990	HDiff	0.986	0.0112	0.0056	0.04
								HAid	0.986	−0.0009	0.0026	0.74
Hoffman et al.18	ISG20	rs4932196	15	89253268	T	C	1.000	HDiff	0.809	0.0085	0.0017	4.60E−07
								HAid	0.809	0.0039	0.0008	6.40E−07
	TRIOBP	rs5756795a	22	38122122	T	C	1	HDiff	0.539	−0.0092	0.0013	5.10E−12
								HAid	0.538	−0.0027	0.0006	1.60E−05

Definition of terms: study, publication of previous finding; gene, gene highlighted in the referenced publication as the lead SNP is either located in the gene region or in close proximity; SNP, single-nucleotide polymorphism; CHR, chromosome; BP, base position; A1, effect allele in analysis; A0, reference allele; INFO, quality metric, combination of imputation score and dosage confidence; UKBB phenotype, phenotype used in this study; A1FREQ, frequency of effect allele in analysis sample; BETA, effect size from BOLT-LMM approximation to infinitesimal mixed model; SE, standard error of the effect size; p value, infinitesimal mixed model association test p value.

^aThis study did not analyze SNP rs58389158, but analyzed rs5756795 which is in complete LD with this SNP in the British population, and referenced in the previous study.