Table 3.
Immunopathological and immunological characteristics of the reported patients with anti-p200 pemphigoid.
| Number of reported cases | ||
|---|---|---|
| Direct immunofluorescence, n (%) | ||
| Linear deposition along the BMZ | 113 (100%) | 113 |
| Linear deposition of IgG and C3 | 77 (78.6%) | 98 |
| Linear deposition of IgG, IgA, and C3 | 10 (10.2%) | 98 |
| Linear deposition of C3 alone | 4 (4.1%) | 98 |
| Linear deposition of IgG, IgA, IgM, and C3 | 2 (2.0%) | 98 |
| Linear deposition of IgG alone | 2 (2.0%) | 98 |
| N-serration deposition pattern | 11 (84.6%) | 13 |
| U-serration deposition pattern | 0 (0%) | 13 |
| Undetermined deposition pattern | 2 (15.4%) | 13 |
| NaCl-split indirect immunofluorescence deposition, n (%) | ||
| Dermal side | 90 (83.3%) | 108 |
| Both dermal and epidermal sides (more prominently in the dermal side) | 16 (14.8%) | 108 |
| Epidermal side | 1 (0.9%) | 108 |
| Negative | 1 (0.9%) | 108 |
| Immunoblot analysis, n (%) | ||
| 200-kDa dermal protein | 111 (100%) | 111 |
| Recombinant C-terminus of laminin γ1 | 19 (73.1%) | 26 |
| ELISA detecting recombinant monomeric C-terminal fragment of human laminin γ1, n (%) | ||
| 10 (100%) | 10 | |
n, number; BMZ, basement membrane zone; Ig, immunoglobulin; ELISA, enzyme-linked immunosorbent assay. The right column represents the number of cases where the variable was reported or could be concluded. The ratios represent the number of positive cases out of the number of reported cases.