Table 1.
Mutations identified in the HvATR gene.
| Allele | Mutation position in gDNA (in CDS) | State of mutation in M2 plant | Type of mutation | Effect in protein | Mutated domain |
|---|---|---|---|---|---|
| hvatr.a | G11111A; G7524A | Homozygous | Silent | – | |
| hvatr.b | C11060T; C7473T | Heterozygous | Silent | – | |
| hvatr.c | G10792A; G7317A | Heterozygous | Silent | – | |
| hvatr.d | C11104T; C7517T | Heterozygous | Missense | A2506V (alanine to valine) | PIKKc |
| hvatr.e | C6023T; C3012T | Homozygous | Silent | ||
| hvatr.f | G5682A; G2767A | Homozygous | Missense | E923K (glutamic acid to lysine) | UME |
| hvatr.g | G6054A; G3043 | Heterozygous | Missense | G1015S (glycine to serine) | UME |
| hvatr.h | G6146A; G3135A | Homozygous | Silent | – | |
| hvatr.i | G5623A; G2708A | Heterozygous | Missense | G903E (glycine to glutamic acid) | UME |
| hvatr.j | G10693A; G7218A | Heterozygous | Silent | – | |
| hvatr.k | G10945A; - | Heterozygous | Intronic | – | |
| hvatr.l | G10486A; G7011A | Homozygous | Silent | – | |
| hvatr.m | C10978T; C7391T | Heterozygous | Missense |
A2464V (alanine to valine) |
PIKKc |
| hvatr.n | G10453A; G6978A | Homozygous | Silent | – | |
| hvatr.o | C10574T; C7099T | Homozygous | Missense | L2367F (leucine to phenylalanine) | PIKKc |
| hvatr.p | T10604C; T7129C | Homozygous | Missense | W2377R (tryptophan to arginine) | PIKKc |
| hvatr.r | C10871T;- | Heterozygous | Intronic | – |
The alleles that carry missense mutations are bolded.