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. 2019 Oct 22;10:1280. doi: 10.3389/fphys.2019.01280

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Copyright © 2019 Bacqué-Cazenave, Fossat, Issa, Edwards, Delbecque and Cattaert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Excitatory effects induced by 5-HT cell activation on Dep MNs. (A1) Depolarizing response of an intracellularly recorded Dep MN to the ipsilaterally projecting A1 5-HT cell intracellular stimulation. (A2) Excitatory effect of 5-HT cell activation on 10 Dep MNs. Square symbol represents trace used in A1. (A3) Increased input resistance (R_in) from six MNs when 5-HT cells are stimulated. Membrane potential of these MNs increases also. Square symbol represents trace used in A1. (B1) Increase of the amplitude of the sensory-motor response of an intracellularly recorded Dep MN during 5-HT cell activation. In this experiment (same as panel A1), sinewave movements (Mvt) were continuously applied to the CBCO strand and evoked sensory discharges recorded from the CBCO sensory nerve (CBCO). Before 5-HT cell stimulation (left column), the Dep MN depolarized during CBCO release movements (corresponding the leg levation in intact animal) and repolarized during CBCO stretch. After 5 min of 5-HT cell stimulation (right), the Dep MN potential depolarized from −83.2 to −75.6 mV and the amplitude of the sensory-motor response increased. (B2) In this experiment, the 5-HT cell stimulation significantly increased the amplitude of the Dep MN sensory-motor response from 0.99 ± 0.06 mV (averaged from 20 cycles) in control condition to 1.64 ± 0.099 mV (averaged from 20 cycles) after 5-HT cell stimulation. (B3) Increase of sensory-motor response recorded from six MNs, after the 5-HT cell stimulation. (C1) Examples of unitary EPSPs’ shape changes induced in Dep MN that showed a depolarizing response to 5-HT cell activation. In control condition and after 5-HT cell stimulation, superimposed examples (raw data, light traces) and corresponding average EPSP traces (dark traces) are presented. (C2): Mean EPSP amplitudes measured at peak (black arrows) and 15 ms after peak in the late part of the decay phase (gray arrows). These unitary EPSPs are recorded in the same Dep MN.